Candidate Feedback

CHRONIC DIARRHEA:        A 75-year old retired school teacher used the product starting January 9 2014 to treat bowel irregularities resulting from chemotherapy and radiation treatment to remove a small cancerous lesion located near the anal sphincter. His major distraction after a year following the treatment was frequent diarrheal episodes with major reliance on intake of loperamide tablets to control the diarrhea.

After four weeks of once daily ingestion of the formulation before retiring in the evening, he was able to have much more normal bowel movements without having to rely on loperamide. In these four weeks he used only a total of four loperamide caplets on two occasions—two on week one of taking the powders and two on week three.  Apart from those occasions when diarrhea arose, he had much more normal stool mass with bowel movements at least twice each day and sometimes three but without the need to resort to loperamide usage. Excess flatulence resulting from the cancer treatment was not further impacted by the formulation ingestion.

Following a week without treatment and decision to restart the powder regimen, he had a vigorous but short diarrheal episode at three AM following the first powder ingestion before retiring and had to resort to 2 loperamide caplets to control the episode. Later the following day he had a normal firm stool discharge. After 10 more days of regular daily ingestion of the formulation, his comments were “What a significant change! I have been as regular and normal as I have ever been with my lower digestive tract activity”. In the past three weeks without the product he has had only one rapid discharge accident and that after two early morning normal bowel movements. He was unsure of the cause and thought it may be due to some particular food item or just a nasty interaction with digestive gas. Normally he is able to read the condition of his digestive tract but “I really missed that one”. With that one exception he comments that he was proud of his regularity and has requested additional sachets.

In a 6½-month follow-up on July 23, the volunteer reports that he is well as far as his digestive tract issues are concerned. His digestive tract only acts up when a certain food issue causes a change in his bowel regularity routine – an issue arising less than once every two weeks with possible need for a loperamide caplet. He continues taking the product daily and his final comment was that it is “very nice to have more normal bowel movements”.

In a 10-month follow-up on October 16 while still on our product, the volunteer provided an update on his GI condition. No changes in his excess gas situation while on the product – a problem existing even before his chemotherapy and radiation treatment. His daily bowel movements remain unchanged at 2 or 3 but “arguably less diarrhea and really soft stools and that in the context of no big changes in my dietary habits the past year”. Loperamide usage as an escape medication has been reduced significantly from twice weekly before our product to not more frequent than twice a month during the past ten months. He continues to receive our product.

SEVERE HEARTBURN:     A retired male individual who had undergone heart bypass surgery in 2011 started to use our product in March 2014. In addition to heart medications (Crestor, Metoprolol & Plavix) prescribed following the surgery, his physician recently (January 2014) prescribed ranitidine to treat recurring incidences of abdominal pain and burning sensations in the throat. These GERD-related reactions were so severe on two earlier occasions (2012, 2013) that he needed to seek treatment at local hospitals. Ranitidine had provided him with some relief but still evidence of discomfort and pain in his abdomen.

Following week 1 of the formulation daily ingestion, he observed only slight abdominal pain and sporadic incidences of burning sensations in the throat throughout the week. After the second week, he recorded no abdominal pain and no burning sensations in the throat or stomach. He described his condition at the time as “VERY GOOD” and felt that “there is life in my body. This improvement continued during the following two weeks. In a recent update request (~ 6 weeks post product initiation) he recorded that during the past two weeks “I did not have any problems what so ever. I felt great, no bloating or burning stomach”. After 6-8 weeks of treatment he feels cured and advised our group he has no further need for the product. At our request he confirmed that he had not taken ranitidine during the time he was on Prebiox Plus treatment.

On contacting him July 18 on his condition after 4½ months, his response was “ condition is still very well and without abdominal pain and I am very thankful for your contribution of Prebiox Plus”.

CROHN’S DISEASE (CD):   Product samples were provided on April 28 2014 to a family of a 3½ year-old boy (born 10 weeks premature) who was diagnosed with CD by a gastroenterologist in November 2013. Up to June 2014, the child had been treated with two different steroid treatments (more recently Entocort) as well as Pentasa and sulfa drugs as required for treating the condition. Both colonoscopy and endoscopy procedures were performed on the child and showed severe inflammation of the entire GI tract confirmed by duodenal mucosal biopsies and stomach granulomas. The child had stunted growth, little weight gain, and from 18 months old has suffered with severe diarrhea consisting of liquid stool comprised of blood and mucus.

Initially our product was provided in single sachets containing the same dosage format (2500 mg short chain fructooligosaccharides or scFOS, 2500 mg oligofructose-enriched inulin and 300 mg epigallocatechin 3-gallate or EGCG) and mixed-berry flavored product approved by the NHPD of Health Canada for adults and advised the parents to reconstitute the product in water (120-150 mL) as usual, give him half the liquid on day one and refrigerate the remainder for the next day. Administration of our product commenced (July 1) following the end of his last steroid treatment and with the knowledge and approval of the gastroenterologist. Three weeks treatment of the formulation provided some flavor problems for the child (adult-oriented flavors) but also some encouraging signs: improved bowel habits (1 bowel movement daily), alleviation of abdominal pain, better facial coloring and improved appetite.

Diet adjustment during the 8 weeks on the product proved to be a problem on several occasions – too little fiber intake led to two days of constipation, introduction of fiber in the form of peaches and cherries led to more liquefied stools but devoid of blood and mucous. Elimination of the fruit led to an improved situation and after a six-day period he was back to once-a-day bowel movements where “his “stool is not solid, neither is it diarrhea”. The mother further comments that “This is significant for him. We are further encouraged because a week ago, he caught a cold. Normally, in (sic) case, this could be a precursor to diarrhea increase, as the Crohn’s disease becomes more active with the immune system’s increased activity…but as I said, bowel movements right now are fine”.

Unflavored samples of same daily dosage were ultimately supplied to the parents but in divided doses i.e., 625 mg each of scFOS and oligofructose-enriched inulin and 75 mg EGCG in individual sachets. The material was supplied free of flavours, sweeteners and buffering agents so that the parents could dissolve in water and blend with a beverage or drink according to the son’s preference. The parents were instructed to administer one of the dosages in the morning and the other in the afternoon. The mother’s update after several days on this new regimen is quoted from her email: “He actually had a formed stool Monday evening. In his entire little lifespan, he’s only once had a formed stool. We really are excited at the toilet training progress and fact that (sic) is without a pharmaceutical drug.“

On August 26 the parent wrote that they had used up the remaining sachets 5 days prior and that her son on that day had a flare-up consisting of 4 bowel movements, two or three of which had blood leaving her to guess about the cause, e.g., stoppage of our product, due to a previous cold encounter or possible dietary ingredient! Two days later the son’s bowel habits had returned to “normal” and additional product samples have been forwarded to the parents with a dosage recommendation to initiate 2 sachets daily for a 4-day period and then one sachet daily thereafter.

On September 3 the parent remarked that her son had one more day of 4 bowel movements in the 2-week period without our product but returned to normal the following day. A visit to the GE on the same day provided the parents with some reassuring words from the specialist on their son’s progress to date and requested that they continue treatment with our product. The doctor had requested blood work to be done on their son and the results came back with the comments “remarkably good and the best it’s been thus far”. We have requested copies of the old and new blood results from the parents but in the meantime we will continue to supply the parents with material.


On June 30, 2015 the boy with Crohn’s Disease will have completed one (1) year of Prebiox Plus administration combined with varying drug products. For the past 5 months he has only been on azathioprine and Prebiox Plus. At a recent GI appointment, the practitioner asked the parents what supplements they were administering to the child. They mentioned Prebiox Plus and the practitioner jotted down the web site and told the parents “to keep up with the Prebiox as it is obviously helping the little guy”.

The child is still on our product as of this date (December 2015) and currently used along with Azathioprine. During this span of a year, the child has had numerous occurrences of diarrheal episodes brought on by colds or a certain dietary ingredient. At a June 2015 appointment with their GI specialist, the practitioner asked the parents what supplements the child was taking. The parents mentioned our product to the doctor who jotted down our website and told the parents to maintain the product as it “is obviously helping the little guy”. A similar request made at an October 2015 appointment by the attending physician who requested the parents to advise when the product was on the market. At the time of this last visit the child had been without a flare-up for 6 months.